AUVI-Q® (epinephrine injection, USP) is indicated in the
emergency treatment of allergic reactions (Type I) including anaphylaxis
to allergens, idiopathic and exercise-induced anaphylaxis. AUVI-Q is
intended for patients with a history of anaphylactic reactions or who
are at increased risk for anaphylaxis.
IMPORTANT SAFETY INFORMATION
AUVI-Q is intended for immediate self-administration as emergency
supportive therapy only and is not a substitute for immediate medical
In conjunction with the administration of epinephrine, the patient
should seek immediate medical or hospital care.
Each AUVI-Q contains a single dose of epinephrine for single-use
injection. More than two sequential doses of epinephrine should only be
administered under direct medical supervision. Since the doses of
epinephrine delivered from AUVI-Q are fixed, consider using other forms of
injectable epinephrine if doses lower than 0.1 mg are deemed necessary.
AUVI-Q should ONLY be injected into the anterolateral aspect of the
thigh. Do not inject intravenously, or into buttock, digits, hands, or
feet. Instruct caregivers to hold the leg of young children and infants
firmly in place and limit movement prior to and during injection to
minimize the risk of injection-related injury.
Rare cases of serious skin and soft tissue infections have been reported
following epinephrine injection. Advise patients to seek medical care if
they develop any of the following symptoms at an injection site: redness
that does not go away, swelling, tenderness, or the area feels warm to the
Epinephrine should be administered with caution to patients with certain
heart diseases, and in patients who are on medications that may sensitize
the heart to arrhythmias, because it may precipitate or aggravate angina
pectoris and produce ventricular arrhythmias. Arrhythmias, including fatal
ventricular fibrillation, have been reported in patients with underlying
cardiac disease or taking cardiac glycosides or diuretics. Patients with
certain medical conditions or who take certain medications for allergies,
depression, thyroid disorders, diabetes, and hypertension, may be at
greater risk for adverse reactions. Common adverse reactions to
epinephrine include anxiety, apprehensiveness, restlessness, tremor,
weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting,
headache, and/or respiratory difficulties.
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